Full Answer
Does nicotine interact with codeine?
Summary: Nicotine use over time increases the speed that codeine is converted into morphine within the brain, by increasing the amount of a specific enzyme, according to new research in rat models.
Does vaping interfere with medication?
Quitting Smoking and Vaping and Psychiatric Medications Fortunately, nicotine-replacement therapy does not interfere with antidepressant or antipsychotic medications.
Can you vape with acetaminophen?
No interactions were found between nicotine and Tylenol.
What is Promethazine VC w codeine?
Promethazine VC with Codeine Oral Solution is a prescription medicine used to temporarily treat cough and upper respiratory symptoms, including a stuffy nose (nasal congestion) that you can have with allergies or a common cold.
What drugs does nicotine interact with?
The chemicals in smoke may interact with antipsychotics, antidepressants, benzodiazepines,8 oral contraceptives, inhaled corticosteroids and beta blockers via pharmacokinetic and pharmacodynamic (often nicotine-mediated) mechanisms.
Is it OK to smoke after taking medicine?
Patients taking these medicines should be monitored for overdose effects and dose adjustments made if necessary. Smoking may also cause pharmacodynamic interactions such as: increased risk of cardiovascular adverse effects with the combined hormonal contraceptive. decreased efficacy of inhaled corticosteroids.
Why does my head hurt when I vape?
Nicotine affects the blood vessels in your brain, causing them to narrow. This reduces blood flow to your brain and can cause headaches in some people. Since nicotine is a stimulant, it may also make some people's nerves more sensitive to pain.
Can vaping cause brain aneurysm?
Vaping Increases Risk of Brain Hemorrhage and Aneurysm A study in the October 2018 edition of Stroke notes nicotine can play a role in intracranial aneurysm ruptures.
Why does it hurt when I vape?
Some may include nicotine, propylene glycol, diacetyl, and volatile organic compounds. Taking a dry hit or using vaping liquid with less nicotine than you are used to can lead to a sore throat. Some chemicals found in vaping liquid can also trigger a dry and/or sore throat.
Is promethazine a narcotic?
A year after it entered the U.S. market, a combination drug of promethazine hydrochloride and codeine (a prescription narcotic) was introduced for common-cold symptoms and cough. However, the substance has also been misused as a potentially dangerous illegal street drug called “drank” or “sizzurp.”
Does plain promethazine make you sleepy?
It's a good option, because it's available as a lower-cost, generic medication. Promethazine VC can make you very sleepy and should not be used in children younger than 2 years old or in people with certain heart or breathing problems.
Can promethazine cough syrup make you sleepy?
Drowsiness, dizziness, blurred vision, nausea, constipation, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
What Is Promethazine With Codeine?
Codeine is a narcotic. It is a pain reliever and a cough suppressant. Promethazine is an antihistamine. It blocks the effects of the naturally occu...
Before Taking This Medicine
You should not use this medicine if you are allergic to codeine or promethazine, or if you have asthma, pneumonia, or other lung problems.In some p...
How Should I Take Promethazine With Codeine?
Follow all directions on your prescription label. Promethazine with Codeine can slow or stop your breathing. Never use this medicine in larger amou...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A codeine overdose can be fatal, especially in a child or other pe...
What Should I Avoid While Taking Promethazine With Codeine?
This medicine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizzine...
Promethazine With Codeine Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Li...
What Other Drugs Will Affect Promethazine With Codeine?
Some medicines can interact with Promethazine with Codeine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if yo...
How to dispose of Promethazine?
1) Remove them from their original containers and mix them with an undesirable substance, such as used coffee grounds or ki tty litter (this makes the drug less appealing to children and pets, and unrecognizable to people who may intentionally go through the trash seeking drugs). 2) Place the mixture in a sealable bag, empty can, or other container to prevent the drug from leaking or breaking out of a garbage bag, or to dispose of in accordance with local state guidelines and/or regulations .
What are the risks of using benzodiazepines with codeine?
Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants. Concomitant use of opioids, including Promethazine with Codeine Oral Solution, with benzodiazepines, or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
How is codeine metabolized?
Codeine is metabolized by conjugation with glucuronic acid to codeine-6-glucuronide (about 70 to 80%), by O-demethylation to morphine (about 5 to 10%), and by N-demethylation to norcodeine (about 10%). UDP-glucuronosyltransferase (UGT) 2B7 and 2B4 are the major enzymes mediating glucuronidation of codeine to C6G. Cytochrome P450 2D6 is the major enzyme responsible for conversion of codeine to morphine and P450 3A4 is the major enzyme mediating conversion of codeine to norcodeine. Morphine and norcodeine are further metabolized by conjugation with glucuronic acid. The glucuronide metabolites of morphine are morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). Morphine and its M6 glucuronide conjugate are pharmacologically active. Whether C6G has pharmacological activity is unknown. Norcodeine and M3 glucuronide conjugate of morphine are generally not considered to be pharmacologically active.
How does codeine affect the central nervous system?
Effects on the Central Nervous System. Codeine produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and to electrical stimulation.
How much promethazine is in a 5ml solution?
Each 5 mL of Promethazine with Codeine Oral Solution contains 10 mg of codeine phosphate and 6.25 mg of promethazine hydrochloride for oral administration.
What is the best oral solution for cough?
Promethazine with Codeine Oral Solution is indicated for the temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older.
What is the chemical name for codeine phosphate?
The chemical name for codeine phosphate is 7,8-Didehydro -4, 5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate. Codeine is one of the naturally occurring phenanthrene alkaloids of opium derived from the opium poppy, it is classified pharmacologically as a narcotic analgesic. The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and slightly soluble in alcohol. The molecular weight is 406.37. Its molecular formula is C 18 H 21 NO 3 • H 3 PO 4 • ½H 2 O and it has the following chemical structure.
What are the side effects of taking codeine?
Check with your doctor immediately if any of the following side effects occur while taking codeine / phenylephrine / promethazine: Incidence not known. Black, tarry stools. bleeding gums.
Does promethazine cause hyperexcitability?
Promethazine use has resulted in paradoxical reactions described as hyperexcitability and abnormal movements. This has occurred following 1 dose and in some patients accompanied by respiratory depression, nightmares, delirium, and agitated behavior.
Can promethazine be used during pregnancy?
Prolonged use of promethazine hydrochloride/phenylephrine hydrochloride/codeine phosphate oral solution during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. If promethazine hydrochloride/phenylephrine hydrochloride/codeine phosphate oral solution is used for ...
Is promethazine a respiratory depressant?
Children may be particularly sensitive to the additive respiratory depressant effects when promethazine is combined with other respiratory depressants, including codeine.Ensure accuracy when prescribing, dispensing, and administering promethazine hydrochloride/phenylephrine hydrochloride/codeine phosphate oral solution.
Does codeine need immediate medical attention?
Side effects not requiring immediate medical attention. Some side effects of codeine / phenylephrine / promethazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Does codeine cause respiratory depression?
Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy.
What is the difference between promethazine and codeine?
Codeine and promethazine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Codeine and promethazine contains an opioid (narcotic) cough medicine, and may be habit-forming. Codeine and promethazine may also be used for purposes not listed in this medication guide.
What are the side effects of a syringe?
drowsiness, lack of energy; tremors, coordination problems; feeling anxious, restless, nervous, or irritable; urination problems; sweating; or. shortness of breath. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
What MAO inhibitors are used for methylene blue injection?
MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Codeine and promethazine is not approved for use by anyone younger than 12 years old.
What happens if you take opioids while pregnant?
if you have a fever and cough with mucus. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug.
How long does it take for a cough to go away?
Call your doctor if your symptoms do not improve after 5 days of treatment. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture, heat, and light. Keep track of your medicine.
Can codeine cause drowsiness?
A codeine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
Can you take codeine with promethazine?
You should not use codeine and promethazine if you are allergic to codeine or promethazine, or if you have: if you are unable to urinate. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur.
What are the side effects of a syringe?
headache, confusion; dry mouth, nausea, vomiting, constipation; tremors, fast or irregular heart rate; or. feeling anxious, restless, nervous, or irritable. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
How to measure liquid medicine?
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Rinse after each use. Call your doctor if your symptoms do not improve after 5 days, or if you have a fever, rash, or headaches.
What is the best medicine for a runny nose?
Promethazine VC with Codeine is a combination medicine used to treat runny or stuffy nose, sneezing, cough, and sinus congestion caused by allergies or the common cold. Promethazine VC with Codeine contains a narcotic cough medicine and may be habit-forming.
What is a sedative like Xanax?
a sedative like Xanax or Valium ( diazepam, alprazolam, lorazepam, and others); other cough, cold, or allergy medicines; asthma medication; pain medicine or a muscle relaxer; medicine to treat depression, anxiety, mood disorders, or mental illness; heart or blood pressure medication; a diuretic or "water pill";
Can Promethazine cause overdose?
MISUSE OF Promethazine VC with Codeine CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Is Promethazine VC discontinued?
The Promethazine VC with Codeine brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Can you take Promethazine with Codeine?
Never use Promethazine VC with Codeine in larger amounts, or for longer than prescribed. Take this medicine only until your symptoms clear up. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.
What are the side effects of a syringe?
Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Feeling dizzy, sleepy, tired, or weak. Feeling nervous and excitable. Constipation, stomach pain, upset stomach, throwing up, or feeling less hungry. Dry mouth.
What drugs can cause high blood pressure?
This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
Can you take a weed pill with all your drugs?
Many drugs interact with this drug and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use this drug with all of your drugs. Avoid alcohol, marijuana or other forms of cannabis, or prescription or OTC drugs that may slow your actions.
Can you take a sex pill while pregnant?
Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period, or ejaculation problems. If you are 65 or older, use this drug with care. You could have more side effects. This drug may cause harm to the unborn baby if you take it while you are pregnant.
Can you take a cough pill with a cold?
Talk with the doctor. This drug is not for use in children younger than 18 years of age. The benefits of taking this drug for a cough due to allergies, a cold, or other infection do not outweigh the risks in children. If your child has been given this drug or if you have any questions, talk with your child’s doctor.
Is codeine bad for children?
The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breath ing problems have happened with the use of codeine in some children. Talk with the doctor.
Does a benzodiazepine have a side effect?
This drug has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines, alcohol, marijuana or other forms of cannabis, or prescription or OTC drugs that may cause drowsiness or slowed actions. This includes slow or troubled breathing and death.
What is Promethazine-Codeine?
Promethazine-codeine is a prescription drug, for the treatment of cough and cold symptoms, made up of two separate medications. These are codeineand promethazine. Codeine is an opioid that has been used for a very long time to treat pain and as a cough suppressant.
Why is it Dangerous?
One dangerous factor about promethazine-codeine is the fact that it is addictive.
What is the Treatment for Promethazine-Codeine Abuse
The treatment protocols for promethazine-codeine abuse are largely the same as those for other opioids. The best treatment programs involve detox or medication replacement (such as methadone), individual and group counseling that determines the underlying causes of the addiction, and aftercare and support that aims to prevent relapse.
Where to Find a Treatment Center
The dangers associated with the abuse promethazine-codeine cough syrup are now very clear. Using it in a manner other than that prescribed can be very deadly, even if it is only your first time.
Pro Tip for all you guys with questions
Idk if alot of you guys know this but if you type ur question into Google and put reddit at the end chances are someone else has already asked and gotten answers :)
Is it true that aluminum fumes are neurotoxic?
Is inhaling the fumes from aluminum foil neurotoxic? I've heard that it is but I've also heard that it's misinformation. It's obviously bad for your lungs, but what about the brain?
People are saying wax in my area is laced but I trust my dealer
Are there really people dosing wax with fentanyl? Wouldn’t that kill someone if they smoked a g in two days? Can some one tell me the science if that’s actually possible because from what I’ve seen no drug dealers would put fentanyl into wax they’d put it in pills right?
How do you feel ok with being sober?
I don’t know what’s wrong with me. I’m on a shit ton of meds from being institutionalized for like 5 years of my life. The only drug I’ve been super addicted to is nicotine and Kratom. I had a problem with Kratom for a while until I tossed it and decided it was doing worse to my life even though I was able to escape the pain
I took 30mg ritalin xr. Will I die?
I took 30mg ritalin (I believe XR since they are rock hard balls in a capsule).
Do ADHD stimulants (Adderall, Vyvanse, dex) have a cross tolerance with Modafinil?
I have ADHD and take 50mg vyvanse and 10mg dex daily, and have done for a year. However, recently my tolerance is so high that the medication is virtually useless. I am in no way trying to chase the "euphoria" that is associated with the first few weeks of stimulants use.
What are the side effects of codeine?
Sedation. Shortness of breath. Nausea. Vomiting. Sweating. Constipation. Despite its potentially harmful effects, the abuse of prescription cough medicines containing codeine has become popular among teens and young adults, especially those who reside in the southern United States.
What is codeine used for?
Codeine is an opioid drug used to relieve mild to moderate pain and reduce coughing. It can be prescribed in a tablet form, but it is also commonly found in prescription-grade cough syrups or in combination with acetaminophen (Tylenol).
What is the chemical in marijuana?
Marijuana, also commonly referred to as weed, grass, herb, pot, reefer, bud, dope, and Mary Jane, is a mind-altering drug produced by the cannabis plant.3 The chemical tetrahydrocannabinol (THC) found in marijuana is the principal ingredient responsible for its psychoactive effects.
Can marijuana use be misused?
Research has shown that marijuana users are much more likely to misuse prescription opioids and develop a prescription opioid use disorder compared to nonusers.7 Like other opioid drugs, codeine has a high potential for abuse.
Is codeine a depressant?
Although some people may think that codeine is relatively harmless compared to other opioids due to its widespread availability, at a high enough dose codeine can lead to respiratory failure, coma, and even death.4 This risk is especially high when codeine is combined with other central nervous system depressants such as alcohol or other opioids. Although technically not classified as a depressant drug, certain compounds present in marijuana can depress the central nervous system and cause side effects such as lethargy and low energy.5 The depressant properties of marijuana make it extremely dangerous to use in combination with codeine because it may cause an additive effect, resulting in exacerbated suppression of the central nervous system. Studies have shown that the combined use of marijuana with opioids such as codeine results in elevated symptoms of anxiety and depression compared to use of the opioid alone.6 The combined use of marijuana and codeine also increases the likelihood of substance use problems. Research has shown that marijuana users are much more likely to misuse prescription opioids and develop a prescription opioid use disorder compared to nonusers.7 Like other opioid drugs, codeine has a high potential for abuse. As the frequency of codeine use increases a tolerance to the drug develops, increasing the dose needed to experience the desired effects. This pattern will eventually lead to physical dependence, which can be especially difficult to deal with if you also use marijuana. Findings from a recent study suggests that 30% of marijuana users suffer from dependence and will experience withdrawal symptoms when not taking the drug.8
Does codeine cause euphoria?
Although codeine is less potent than other opioid drugs, it still acts on the brain in a similar fashion to provide the user with feelings of euphoria and relaxation. And like other opioids, codeine produces adverse side effects that can include:1. Drowsiness. Lightheadedness. Dizziness.
Is codeine harmful to the body?
Marijuana and opiates, including the prescription drug codeine, are two of the most accessible substances in the United States. The use of these two drugs together can cause interactions that are extremely harmful to the body. Here we will discuss the effects of combining codeine and marijuana.
What is the difference between promethazine and codeine?
Codeine and promethazine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Codeine and promethazine contains an opioid (narcotic) cough medicine, and may be habit-forming. Codeine and promethazine may also be used for purposes not listed in this medication guide.
What to do if someone overdoses on Promethazine?
If you think you or someone else may have overdosed on: Codeine And Promethazine (Promethazine With Codeine) , call your doctor or the Poison Control center. (800) 222-1222. If someone collapses or isn't breathing after taking Codeine And Promethazine (Promethazine With Codeine), call 911. 911.
What happens if you take opioids while pregnant?
if you have a fever and cough with mucus. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug.
How long does it take for a cough to go away?
Call your doctor if your symptoms do not improve after 5 days of treatment. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture, heat, and light. Keep track of your medicine.
What are the side effects of a syringe?
drowsiness, lack of energy; tremors, coordination problems; feeling anxious, restless, nervous, or irritable; urination problems; sweating; or. shortness of breath. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Is codeine a MAO inhibitor?
A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Codeine and promethazine is not approved for use by anyone younger than 12 years old.